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Biology of Reproduction, Vol 1, 31-40, Copyright © 1969 by Society for the Study of Reproduction

Effects of Endocrinectomy and Hormone Replacement Therapies upon RNA Synthesis in Isolated Lactating Rat Mammary Gland Nuclei

R. L. BALDWIN 1, G. O. KORSRUD 1, R. J. MARTIN 1, W. CHENG 1, , and N. A. SCHOBER 1

1 Department of Animal Science, University of California, Davis, California 95616


A study of the effects of alloxan diabetes, ovariectomy, adrenalectomy, hypophysectomy and appropriate hormone replacement therapies upon mammary nuclear RNA polymerase activities and patterns of mammary nuclear RNA synthesis was undertaken to ascertain the extent and specificity of hormonal regulation of nuclear RNA synthesis in lactating rat mammary glands. Alloxan diabetes, ovariectomy and administration of estrogen appeared not to affect patterns of RNA synthesis. These observations may be related to observed specific effects of these hormones upon enzyme patterns and protein synthesis observed in previous studies. The primary types of RNA synthesized by isolated mammary gland nuclei corresponded in base composition to DNA-like RNA and to RNA’s with sedimentation values between 10 and 15S which have been reported to have high levels of messenger-RNA activity.

Submitted on September 11, 1968






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Copyright © 1969 by the Society for the Study of Reproduction.