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Biology of Reproduction, Vol 1, 49-58, Copyright © 1969 by Society for the Study of Reproduction

The Effect of Antisera to Bovine LH in Hysterectomized and Intact Heifers

R. B. SNOOK 1, M. A. BRUNNER 1, R. R. SAATMAN 1, , and W. HANSEL 1

1 Cornell University, Ithaca, New York 14850


Injection of antiserum to bovine LH into hysterectomized heifers caused significant decreases in corpus luteum weight, total progesterone, total progestins and 20beta-hydroxypregn-4-en-3-one (20-beta-ol) concentration but had no effect on progesterone concentration. Gonadotropin secreting cells in the anterior pituitaries of these heifers were markedly degranulated and pituitary LH contents lowered. Thyroid epithelial cell heights were lowered suggesting that the antiserum also contained anti-TSH. The administration of antibovine LH to cyclic heifers from Day 2 to Day 6 of the cycle caused a significant decrease in corpus luteum weight and total progesterone content, but only a slight decrease in progesterone concentration. Histological signs of regression were clearly evident in the corpora lutea of the hysterectomized anti-LH treated heifers, but little difference could be noted between the corpora lutea of control and treated cyclic animals.

Injection of 50 ml of antibovine LH daily from Day 2 to Day 6 of the cycle increased the interval between corpus luteum removal at Day 11 and return to estrus. Injections of 50 ml of antibovine LH daily from Day 12 to Day 16 and from Day 16 to Day 20 of the cycle increased the lengths of the treatment cycles to 28.5 and 36.7 days, respectively. The first post-treatment cycle in both groups was significantly shortened. The increase in cycle length was primarily due to a failure of follicles to develop to mature size, rather than to prolongation of the life span of the corpora lutea. The results of these experiments indicated that LH is required for follicular development and maturation and for the induction of estrus, as well as for corpus luteum maintenance.

 Submitted on October 22, 1968




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G. D. Niswender, J. L. Juengel, P. J. Silva, M. K. Rollyson, and E. W. McIntush
Mechanisms Controlling the Function and Life Span of the Corpus Luteum
Physiol Rev, January 1, 2000; 80(1): 1 - 29.
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Copyright © 1969 by the Society for the Study of Reproduction.