Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 1, 223-227, Copyright © 1969 by Society for the Study of Reproduction

Inhibition of in Vitro Fertilization of Rabbit Ova by Trypsin Inhibitors

RICHARD STAMBAUGH 1, BENJAMIN G. BRACKETT 1, , and LUIGI MASTROIANNI 1

1 Division of Reproductive Biology, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104


Crystalline ovomucoid and soybean trypsin inhibitors were used to inhibit in vitro fertilization of rabbit ova by capacitated rabbit sperm. Cleavage was determined in 222 control ova and in 244 ova treated with an inhibitor. The data demonstrate that there is good correlation between the percentage inhibition of the trypsin-like enzyme of the rabbit sperm acrosome by the inhibitor and the percentage inhibition of in vitro fertilization by the inhibitor. These results provide additional evidence that the trypsin-like component of the rabbit sperm acrosome is essential for dissolution and penetration of the zona pellucida by the spermatozoon.

Submitted on February 3, 1969




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Copyright © 1969 by the Society for the Study of Reproduction.