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Biology of Reproduction, Vol 1, 247-252, Copyright © 1969 by Society for the Study of Reproduction

Stimulation of Blastocyst Implantation in Long Term Hypophysectomized and Ovariectomized Pregnant Rats by Means of Androgens

PUTTIPONGSE VARAVUDHI 1

1 Department of Biology, Chulalongkorn University, Bangkok, Thailand, and Division of Population Dynamics, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205


About 140 rats were subjected to one or more of the following operative procedures to study the hormonal factors involved in nidation: hypophysectomy, ovariectomy, adrenalectomy and partial hepatectomy. A single dose of four different androgens induced nidation in hypophysectomized pregnant rats treated with progesterone. Testosterone propionate (TP) and related androgens were more effective than 5agr-androstane. The minimal effective dose of TP was 0.008 mg when applied to the ovarian capsule; 1.0 mg intramuscularly was required in animals ovariectomized prior to progesterone-androgen treatment. There was no evidence of a direct effect of androgens on implantation since a high dose of TP (50 µg) applied directly to the uterine mesometrium failed to stimulate nidation in hypophysectomized animals which were ovariectomized prior to TP and progesterone treatment.

It is suggested that ovarian tissue of hypophysectomized pregnant rats can convert testosterone-like androgens into estrogen or estrogen-like substance(s) required for nidation. Evidence also favors the existence of a minor site(s) of androgen conversion of extra-ovarian and adrenal origin.

 Submitted on March 5, 1969






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Copyright © 1969 by the Society for the Study of Reproduction.