Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 1, 258-263, Copyright © 1969 by Society for the Study of Reproduction

The Role of Uterine Inflammation in the Inhibition of Decidualization by Intraluminal Antihistamines

EARL PARR 1

1 The Rockefeller University, New York, New Fork 10021


It is well known that the decidual transformation of the rat uterus can be inhibited by the intraluminal administration of antihistaminic drugs. Recent studies on intrauterine foreign bodies in rats have indicated that a uterine inflammatory reaction can also inhibit decidualization. It was therefore of interest to determine whether uterine inflammation might result from the intraluminal administration of antibistaminic drugs in doses sufficient to inhibit decidualization. Four antihistaminic drugs were used. Each was administered at a dose of 1.0 mg per horn to the lumen of one uterine horn in six rats on Day 2 of pregnancy. In all animals this treatment resulted in an inflammatory reaction in the endometrium on Day 5 of pregnancy.

In addition, 1.0 mg of Dibenamine was administered to the lumen of one uterine horn in six rats and inflammation was again noted in each case. Dibenamine at 1.0 mg per horn completely prevented decidualization in one horn in five rats, and at 0.5 mg per horn resulted in an average inhibition of 79% in one horn in six rats. Dibenamine is an adrenergic blocking agent with very little antihistaminic activity, and it would not be expected to inhibit decidualization in this dose range if only antihistaminic activity were involved. These observations suggest that the inhibition of decidualization produced by intraluminal antihistamines is due to uterine inflammation, rather than to the antihistaminic activity. This interpretation conflicts with the proposal that histamine may be the physiological inducer of the decidual reaction.

 Submitted on March 24, 1969






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Copyright © 1969 by the Society for the Study of Reproduction.