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Biology of Reproduction, Vol 1, 289-294, Copyright © 1969 by Society for the Study of Reproduction

Effect of Chlorpropamide upon Prenatal Losses in Rabbits

R. A. BATTAGLIA 1, and T. N. MEACHAM 1

1 Animal Science Department, Virginia Polytechnic Institute, Blacksburg, Virginia 24060


Thirty-nine rabbit pregnancies were divided into three treated groups of ten each and a control group of nine to determine the amount and distribution of prenatal losses when the gestating does were fed 6 mg daily of an oral hypoglycemic agent, chlorpropamide. Group I (control) received the same basal ration as the treated groups. Groups II, III, and IV received the basal ration plus the drug for 5, 15, and 32 days post-coitus, respectively. Preimplantation loss means, determined during laparotomy, for groups I, II, III, and IV were 5.2, 5.0, 4.1, and 7.5%, respectively. The preimplanation losses for groups II, III, and IV were not significantly different from the control group's losses.

The postimplantation loss estimate of 41.8% for the control group was significantly greater (p < .01) than the losses of 8.8, 9.3, and 7.3% observed for groups II, III, and IV, respectively. The total loss estimate of 44.8% for the control group was also significantly greater (p < .01) than the estimates of 13.7, 12.8, and 14.6% for groups II, III, and IV, respectively. These data indicate that the prenatal mortality normally observed in rabbits can be markedly reduced by the feeding of chlorpropamide for the first 5 days following breeding. A further analysis of the preimplantation, postimplantation, and total loss data indicates that no greater increase in prenatal survivability was achieved by feeding the chlorpropamide for more than 5 days.

There was a 10% increase in mean birth weights for the treated groups, indicating a heightened metabolic transfer between the fetus and dam. A marked drop in blood glucose levels for all groups was noted after 15 days gestation.

 Submitted on April 21, 1969






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Copyright © 1969 by the Society for the Study of Reproduction.