Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 10, 474-479, Copyright © 1974 by Society for the Study of Reproduction

Pineal HIOMT Activity in the Rat: Effect of Ovariectomy and Hormone Replacement

EDWARD P. WALLEN 1, and JEROME M. YOCHIM 1

1 Department of Physiology and Cell Biology, University of Kansas, Lawrence, Kansas 66045


The present series of experiments tested the effects of ovariectomy and estrogen replacement on the pattern of HIOMT activity in the pineal gland of the rat. Removal of the ovaries significantly decreased the mean rate of enzyme activity below that measured during the estrous cycle of intact rats, but did not modify the characteristic enzyme rhythmicity. Daily estrogen injections, administered to rats ovariectomized during metestrus of the cycle, restored the mean rate of enzyme activity to the level measured in intact rats. However, the rhythmic pattern, measured in both intact and ovariectomized animals, was distorted as a result of the estrogen replacement therapy. The results demonstrated that (a) the rhythmicity of the pineal gland as related to the estrous cycle is not dependent on the presence of the ovaries, but that changes in the timing of estrogen replacement therapy can interfere with the pineal rhythm, and (b) there exists a "feedback relationship" between ovarian function and the mean rate of pineal HIOMT activity. The results of the experiments are consistent with the concept of a mixed-wave equation describing pineal HIOMT activity in the rat.

Accepted on October 12, 1973






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Copyright © 1974 by the Society for the Study of Reproduction.