Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KEYES, P. L.
Right arrow Articles by BULLOCK, D W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KEYES, P. L.
Right arrow Articles by BULLOCK, D W.
Agricola
Right arrow Articles by KEYES, P. L.
Right arrow Articles by BULLOCK, D W.

Biology of Reproduction, Vol 10, 519-525, Copyright © 1974 by Society for the Study of Reproduction

Effects of Prostaglandin F2agr on Ectopic and Ovarian Corpora Lutea of the Rabbit

P. LANDIS KEYES 1, and D W. BULLOCK 1

1 Departments of Obstetrics and Gynecology and of Physiology, Albany Medical College, Albany, New York 12208


Dutch-belted rabbits were mated to sterile males (Day 1), and 5 h later the preovulatory follicles from one ovary were transplanted beneath the capsule of the ipsilateral kidney, where they developed into ectopic corpora lutea. On Day 9, the rabbits were randomly assigned to two groups; the animals in one received a single daily subcutaneous injection of prostaglandin F2agr (PGF2agr) in 15% gelatin (400 µg/kg) on Days 9, 10, and 11 and those in the other group received the injection vehicle alone. On Day 12, the ectopic and ovarian corpora lutea were excised, weighed, and fixed in Bouin’s solution for histological examination. In a second experiment, one group of animals received PGF2agr as before and another group PGF2agr plus estradiol-17beta in sesame oil-beeswax (5 µg/animal/day) or estradiol benzoate in oil (3 µg/kg/day). Blood was collected from the ovarian vein and plasma progesterone and estradiol determined, respectively, by a competitive proteinbinding assay and by radioimmunoassay. PGF2agr caused a significant reduction in weight of both ectopic (p < 0.01) and ovarian (p < 0.001) corpora lutea and, respectively, partial and complete histological degeneration of tissues. Concentrations of estradiol in ovarian venous plasma of PGF2agr-treated and control animals were not significantly different; concentrations of progesterone were significantly lower in PGF2agr-treated animals (p < .05). Estrogen treatment restored the weight and histological appearance of both ectopic and ovarian corpora lutea to that of control animals. The results suggest that PGF2agr exerts a direct effect on luteal tissue and demonstrates that the luteolytic effect of PGF2agr in the rabbit is due to interference with the luteotrophic process.

Accepted on November 2, 1973




This article has been cited by other articles:


Home page
 ReproductionHome page
M Zerani, C Dall'Aglio, M Maranesi, A Gobbetti, G Brecchia, F Mercati, and C Boiti
Intraluteal regulation of prostaglandin F2{alpha}-induced prostaglandin biosynthesis in pseudopregnant rabbits
Reproduction, May 1, 2007; 133(5): 1005 - 1016.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1974 by the Society for the Study of Reproduction.