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Biology of Reproduction, Vol 10, 526-532, Copyright © 1974 by Society for the Study of Reproduction

Progesterone and Estrogen Control of Uterine Glucose-6-Phosphate Dehydrogenase Activity during Deciduomal Growth

BRUCE C. MOULTON 1

1 Departments of Obstetrics and Gynecology and of Biological Chemistry, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45229


Uterine glucose-6-phosphate dehydrogenase activity (D-glucose-6-phosphate: NADP+ oxidoreductase, EC 1.1.1.49) was determined in implantation sites during early pregnancy and in deciduomal and myometrial tissues during the growth and regression of the deciduoma during pseudopregnancy. The hormonal control of glucose-6-P dehydrogenase activity in these tissues was determined in further experiments with ovariectomized pseudopregnant rats.

Glucose-6-P dehydrogenase activity was greater in implantation sites than in uterine segments not involved in implantation. In pseudopregnant rats, deciduomal enzyme activity increased during the growth of the deciduoma and decreased during its regression. Enzyme activity in the myometrium remained low during the growth of the deciduoma and then increased. In ovariectomized pseudopregnant rats, glucose-6-P dehydrogenase activity in the deciduoma and myometrium responded differently to each of the ovarian hormones. Deciduomal enzyme activity increased after progesterone treatment, and myometrial enzyme activity increased after estrogen treatment. Both increases in enzyme activity were inhibited by the administration of cycloheximide. Estrogen potentiated the effect of progesterone on glucose-6-P dehydrogenase activity in the deciduoma, but progesterone suppressed the effects of estrogen on the myometrium.

 Accepted on November 2, 1973






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Copyright © 1974 by the Society for the Study of Reproduction.