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Biology of Reproduction, Vol 10, 589-595, Copyright © 1974 by Society for the Study of Reproduction

Adjustments in Maternal Blood Gases, Acid-Base Balance, and Oxygen Consumption in the Pregnant Pygmy Goat

A. S. HOVERSLAND 1, J. METCALFE 1, , and J. T. PARER 1

1 Heart Research Laboratory, Department of Medicine, University of Oregon Medical School, Portland, Oregon 97201


Maternal blood gases (O2 and CO2), plasma pH, and oxygen consumption were studied during pregnancy in resting, unanesthetized Pygmy goats. Eight pregnant and nine nonpregnant animals were studied at 3-wk intervals, beginning before conception and continuing 6 wk postpartum.

During pregnancy, maternal oxygen consumption rose until term when it was 36% higher than the mean postpartum value (227 vs 167 ml/min; p < 0.05). The CO2 concentration declined 13% in arterial blood (41.3 vs 47.2 ml/100 ml; p < 0.01) and 14% in mixed venous blood (43.6 vs 50.7 ml/100 ml; p < 0.01), with lowest values near term. Concurrently, PCOCO2 values declined 13% in arterial blood (32.2 vs 37.1 mmHg; p < 0.05) and 12% in mixed venous blood (36.6 vs 41.3 mmHg; p < 0.01), and plasma bicarbonate declined 12% in arterial blood (20.0 vs 22.7 mmole/liter; p < 0.01) and 14% in mixed venous blood (20.4 vs 23.6 mmole/liter; p < 0.01).

The maternal vascular and cardiodynamic adjustments during pregnancy were adequate to meet the increased O2 requirements of the pregnant doe without drawing on blood O2 reserves, as evidenced by stable values for mixed venous POO2 arteriovenous O2 concentration difference, coefficient of O2 utilization, and plasma pH.

Accepted on November 2, 1973







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Copyright © 1974 by the Society for the Study of Reproduction.