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Biology of Reproduction, Vol 10, 596-604, Copyright © 1974 by Society for the Study of Reproduction

Progesterone Effects Contrasted with 17beta-Estradiol on DNA Synthesis and Epithelial Nuclear Proliferation in the Castrate Rabbit Uterus

Y. KOSEKI 1, and G. I. FUJIMOTO 1

1 Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461


Histologic studies have shown that both progesterone and 17beta-estradiol induce rapid growth and development of the castrate rabbit uterus, but with markedly different expression of effects. We have observed estradiol stimulation of tritiated thymidine incorporation into DNA in all uterine tissues, epithelial, stromal and myometrial, in declining order, reaching maximal rate after 3 days of treatment as determined by radioautographic methods and radiochemical analyses of separated uterine layers. In contrast to this, progesterone promotes uterine hypertrophy and stimulates labeled thymidine incorporation only in epithelial nuclei, both glandular and luminal, commencing 24-30 h after hormone administration and peaking at about 2 days. Progesterone stimulates nuclear synthesis in the epithelium more vigorously than estradiol causing formation of multinuclear cells or multilobed nuclei with extensive invagination of the epithelium. A dose range of progesterone enhancement of uterine wet weight has been determined.

Accepted on November 16, 1973






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Copyright © 1974 by the Society for the Study of Reproduction.