Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 11, 56-63, Copyright © 1974 by Society for the Study of Reproduction

Effects of the Anti-Androgen SK&F 7690 on the Fertility of Epididymal Spermatozoa in the Rabbit

J. M. CUMMINS 1, and M.-C. ORGEBIN-CRIST 1

1 Zoology Department, Victoria University of Wellington, Private Bag, Wellington, New Zealand and Department of Obstetrics and Gynecology Vanderbilt University School of Medicine, Nashville, Tennessee 37203


The anti-androgen SK&F 7690 (17agr-methyl-beta-nortestosterone) was administered subcutaneously to 16 mature male rabbits for 7 days at 100 mg/kg/day. Spermatogenesis was inhibited totally in two, and partially in six of the rabbits, while the remaining eight were unaffected. Testicular damage was in most cases associated with characteristic epithelial lesions in a highly localized region of the caput epididymidis; and also with reductions in the number, and possibly the fertilizing ability of both newly mature spermatozoa from the distal corpus, and fully mature spermatozoa from the cauda epididymidis. Thus, the anti-androgen appears to affect not only spermatogenesis, but also sperm maturation and survival in the epididymis.

Accepted on September 17, 1973






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Copyright © 1974 by the Society for the Study of Reproduction.