Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 11, 180-186, Copyright © 1974 by Society for the Study of Reproduction

Localization, Accumulation, and Toxic Effects of Mercuric Chloride on the Reproductive Axis of the Female Hamster

ALBERT A. LAMPERTI 1, and RICHARD H. PRINTZ 1

1 Department of Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45219


Experiments were performed to determine the mechanism for the effects of mercuric chloride on the reproductive system of the hamster. Tissue levels of mercury were determined in animals which were treated with daily subcutaneous doses of saline, 1 mg of HgCl2, or 1 mg of HgCl2 and 50 mg of N-acetyl-DL-penicillamine (NAP), throughout one 4-day estrous cycle. The relations between concentrations of mercury in several organs were found to be kidney > liver > anterior pituitary > ovary > blood > uterus > hypothalamus > cerebral cortex. Animals which were injected with HgCl2 and NAP had significantly less (p < 0.001) mercury than animals treated with HgCl2 alone in all tissues except the cerebral cortex. Tissues from animals which were injected daily with 12 µCi of 203HgCl2 and 1 mg of HgCl2 were prepared for radioautography. In the ovary, mercury was more concentrated in the corpora lutea than the follicles of interstitium. Mercury was also found lining the sinusoids of the pituitary and in some of the neurons of the arcuate nucleus of the hypothalamus. Explanations for possible alterations in gonadotropin secretion are discussed.

When hamsters were given a total of 3 or 4 mg of HgCl2 during the first cycle, 60% of the animals did not ovulate by Day 1 of the third cycle.

 Accepted on March 5, 1974




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 Toxicol SciHome page
B. J. Davis, H. C. Price, R. W. O'Connor, R. Fernando, A. S. Rowland, and D. L. Morgan
Mercury Vapor and Female Reproductive Toxicity
Toxicol. Sci., February 1, 2001; 59(2): 291 - 296.
[Abstract] [Full Text] [PDF]


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Copyright © 1974 by the Society for the Study of Reproduction.