Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 11, 191-197, Copyright © 1974 by Society for the Study of Reproduction

Luteal Function Following the Infusion of Prostaglandin F2agr into the Uterine Vein of the Ewe

W. A. CHAMLEY 1, J. C. CERINI 1, MILDRED E. CERINI 1, I. A. CUMMING 1, J. R. GODING 1, , and J. D. O'SHEA 1

1 Reproduction Research Section, S.S. Cameron Laboratory, State Research Farm, Werribee, Victoria, Australia


Prostaglandin F2agr (PGF2agr) or saline was infused into sheep on Day 7 or 8 after estrus. Infusions were made into the uterine vein, ipsilateral to the ovary bearing a corpus luteum (CL), or into a jugular vein at dose rates of 1000-20 µg/h for 3-9 h. Plasma progesterone levels were suppressed to low levels in those ewes which received PGF2agr into the uterine vein but not in ewes which received saline into the uterine vein. In three ewes which received PGF2agr by the systemic route (200 µg/h or 500 µg/h for 3 h), some reduction in plasma progesterone concentration occurred in the one animal infused at the higher dose.

These findings give support to the hypothesis that a countercurrent mechanism, by means of which a uterine luteolysin could be transferred from the uterine vein into the ovarian artery, may exist in the sheep. Histological studies in one animal suggest that PGF2agr may cause luteolysis as a result of interference with the arteriolar blood supply of the CL.

 Accepted on March 5, 1974






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Copyright © 1974 by the Society for the Study of Reproduction.