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Biology of Reproduction, Vol 11, 220-233, Copyright © 1974 by Society for the Study of Reproduction
1 Laboratories of Human Reproduction and Reproductive Biology, Harvard Medical School,
45 Shattuck Street, Boston, Massachusetts 02115 The uteri of 44 female rats on Day 5 of pregnancy were subjected to histological
study using 18 different fixation procedures. Irregular protrusions from the apical surface
of luminal epithelial cells were observed with every fixation procedure, indicating that
such surface specializations are not a fixation artifact. A study of the reabsorption of
ferritin from the uterine lumen of four rats on Day 5 of pregnancy showed that the
apical protrusions were involved in the formation of 0.5-3 µm endocytosis vacuoles. Tracer
was taken into these vacuoles within 10-20 min, and by 60 min it was found mostly
in multivesicular and dense bodies. The apical protrusions carried out endocytosis only
on Days 4 and 5 of pregnancy; on Days 1, 2, and 6 this activity was minimal or
absent. In addition to the 0.5-3 µm vacuoles, endocytosis on Day 5 of pregnancy was
also carried out by 100 nm coated vesicles. There was no evidence that the apical protrusions of luminal epithelial cells or the
dome-shaped bulges of glandular epithelial cells pinched off and constituted an apocrine
secretion. We conclude that preimplantation rat embryos are not nourished by an apocrine
secretory process, but that endocytosis may, in some way, be involved in their maintenance.
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