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Biology of Reproduction, Vol 11, 447-462, Copyright © 1974 by Society for the Study of Reproduction

Ultrastructural Study of Secretory Granules in the Corpus Luteum of the Sheep During the Estrous Cycle

R. T. GEMMELL 1, B. D. STACY 1, , and G. D. THORBURN 1

1 Division of Animal Physiology, CSIRO, The Ian Clunies Ross Animal Research Laboratory, Prospect, N.S.W., Australia, and P.O. Box 239, Blacktown, N.S.W., 2148, Australia


The ultrastructure of the corpus luteum of the sheep has been examined throughout the estrous cycle. Small, densely staining granules 0.2 µm in diameter, are observed within the luteal cell at Day 2 of the cycle; they increase in number as the cycle progresses and at Day 6 the first signs of secretion are noticed. Maximum secretion of granules takes place at Days 10 and 11, and this is followed by a progressive decline in secretory activity from Day 12 to Day 15 of the cycle. These clear-cut changes in granule formation and secretion therefore reflect the established pattern of progesterone secretion by the ovary during the estrous cycle in the sheep.

Fractions were obtained from corpora lutea of sheep by homogenization and differential centrifugation. A correlation was obtained between the presence of densely staining granules (approx 0.2 µm diam) and the progesterone content of each fraction.

Many types of nonsteroidogenic endocrine cells are known to have a secretory pathway whereby hormones are packaged in the Golgi region and then discharged from the cells via granules; the present work provides the first indication of a steroid hormone, viz. progesterone, being secreted in a similar way.

 Accepted on June 28, 1974




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J. J. Jaroszewski and W. Hansel
Intraluteal Administration of a Nitric Oxide Synthase Blocker Stimulates Progesterone and Oxytocin Secretion and Prolongs the Life Span of the Bovine Corpus Luteum
Experimental Biology and Medicine, May 1, 2000; 224(1): 50 - 55.
[Abstract] [Full Text]


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Copyright © 1974 by the Society for the Study of Reproduction.