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Biology of Reproduction, Vol 11, 519-528, Copyright © 1974 by Society for the Study of Reproduction

Interceptive Activity of 16agr-Bromoacetoxyprogesterone

STEVEN W. CLARK 1, FREDERICK SWEET 1, , and JAMES C. WARREN 1

1 Departments of Obstetrics-Gynecology and Biological Chemistry, Washington University School of Medicine, St. Louis, Missouri 63110


A local delivery system was utilized to study interruption of pregnancy during the postimplantation period in rats. Intrauterine insertion of control silastic gels in the right cornua on Day 7 of pregnancy had no significant effect on fetal survival. 16agr-Bromoacetoxyprogesterone (l6agr-BAP) and 1lagr-bromoacetoxyprogesterone (llagr-BAP) were effective (p > 0.02) in causing fetal resorptions when applied in similar silastic gels. No contralateral effect was observed with 16agr-BAP or 1lagr-BAP. The other affinity labeling steroids used in this study, 2agr-bromoacetoxyprogesterone, 6beta-bromoacetoxyprogesterone, 21-bromoacetoxyprogesterone, 2agr-bromoprogesterone, 6beta-bromoprogesterone, and the structural analog, 16agr-acetoxyprogesterone did not cause fetal resorption. Intrauterine application of 16agr-BAP significantly inhibited uterine uptake of systemically administered [3H]progesterone in nonpregnant rats, while 2agr-bromoacetoxyprogesterone had no such effect. 16agr-BAP may act as a competitive antiprogestogen, covalently bonding to the progesterone receptor and excluding endogenous progesterone. This interceptive agent is capable of locally interrupting early pregnancy in the rat and does not appear to produce subsequent effects on reproductive patterns.

Accepted on July 23, 1974






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Copyright © 1974 by the Society for the Study of Reproduction.