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Biology of Reproduction, Vol 12, 255-259, Copyright © 1975 by Society for the Study of Reproduction
1 Department of Biochemistry and Division of Urology, Department of Surgery, Vanderbilt University School of
Medicine, Nashville, Tennessee 37232 Lipid and fatty acid composition of testes removed at autopsy from humans aged 56-89 years was
found to be similar to that of testes obtained at orchiectomy from humans of the same age group. It is
suggested, therefore, that the use of autopsy specimens for this type of study is valid. Testes removed at
autopsy from humans aged 19-53 had lipid and fatty acid compositions not significantly different from
the older age group. Histological examination revealed some, but not complete, correlation between the
fatty acid composition and the state of the germinal epithelium. Immature testes of infants had an
altered lipid composition compared to adult tissue, particularly with reference to lower content of the
polyenoic acids. 5, 8, 11 eicosatrienoic and 4, 7, 10, 13, 16, 19 docosahexaenoic acids. In two specimens
of undescended testicles removed from young adults, the tissues were observed to be atrophied and were
found to have decreased concentrations of 5, 8, 11 eicosatrienoic and 4, 7, 10, 13, 16, 19
docosahexaenoic acids. It is suggested that there is a relationship between these two polyenes and the
development of the germinal cells of human tissue.
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