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Biology of Reproduction, Vol 12, 448-454, Copyright © 1975 by Society for the Study of Reproduction

Intracisternal A Particle Formation and Inhibition in Preimplantation Mouse Embryos

Patricia G. Calarco 1

1 Departments of Anatomy and Pediatrics, University of California, San Francisco, California 94143


Intracisternal A particles (IAP) appear in large numbers at approximately the 4 cell stage in murine development. Many cytoplasmic regions containing a few complete IAP’s and budding lAP’s are recognizable in the 2 cell—early 4 cell stages. Zygotes cultured to the 2 cell stage show regions interpreted as earlier stages in IAP formation. These cytoplasmic regions are characterized by fibrous material outlining agranular cisternae of the endoplasmic reticulum, 20 nm granule aggregations and occasionally show IAP budding into the endoplasmic reticulum. These presumptive IAP regions are also seen in zygotes cultured to the 2 cell stage in agr-amanitin but are not present in embryos cultured in actinomycin D. This sensitivity to actinomycin D further underscores the similarities between IAP and mouse oncornaviruses.

Accepted on November 18, 1974






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Copyright © 1975 by the Society for the Study of Reproduction.