Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by OSHIMA, H.
Right arrow Articles by OCHIAI, K.-I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by OSHIMA, H.
Right arrow Articles by OCHIAI, K.-I.
Agricola
Right arrow Articles by OSHIMA, H.
Right arrow Articles by OCHIAI, K.-I.

Biology of Reproduction, Vol 12, 491-497, Copyright © 1975 by Society for the Study of Reproduction

Delay in Sexual Maturation of Rats Caused by Synthetic LH-Releasing Hormone: Enhancement of Steroid Dgr4-5agr-Hydrogenase in Testes

HIROYUKI OSHIMA 1, HOWARD R. NANKIN 1, DER-FONG FAN 1, PHILIP TROEN 1, TAKUMI YANAIHARA 2, NAOKO NIIZATO 3, KEN-ICHIRO YOSHIDA 3, , and KYO-ICHIRO OCHIAI 3

1 Department of Medicine, Montefiore Hospital and the University of Pittsburgh, School of Medicine, 3459 Fifth Avenue, Pittsburgh, Pa. 15213
2 Department of Gynecology and Obstetrics, School of Medicine, Teikyo University, Itabashi-ku, Tokyo, Japan
3 Department of Urology, School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan


Immature 28 day old male rats were injected daily with 0.5 µg of synthetic LRH for either one or two weeks. Control animals were injected with the saline diluent. The treatment with LRH for two weeks significantly decreased the weights of accessory sexual organs. Treatment did not alter testicular weights or cause recognizable morphologic changes of the testes.

Cell-free homogenates prepared from each pair of testes were incubated with either 4-[14C] 17agr-hydroxyprogesterone or 4-[14C] androstenedione. There were no significant differences between the experimental and the corresponding control groups in the amounts of metabolites produced by 17agr-hydroxypregnene C17-C20 lyase and 17beta-hydroxysteroid oxidoreductase. However, Dgr4-5agr-hydrogenase activity significantly increased after administration of synthetic LRH for either one or two weeks, resulting in markedly low formation in vitro of dgr4-3-oxo androgens. This could account for the delay in the development of accessory sexual organs found in rats receiving synthetic LRH.

 Accepted on December 2, 1974






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the Society for the Study of Reproduction.