Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ALBRECHT, E. D.
Right arrow Articles by WEHRENBERG, W. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ALBRECHT, E. D.
Right arrow Articles by WEHRENBERG, W. B.
Agricola
Right arrow Articles by ALBRECHT, E. D.
Right arrow Articles by WEHRENBERG, W. B.

Biology of Reproduction, Vol 13, 158-162, Copyright © 1975 by Society for the Study of Reproduction

Ovarian Dgr5-3beta-Hydroxysteroid Dehydrogenase and Cholesterol in the Aged Mouse During Pregnancy

E. D. ALBRECHT 1, R. D. KOOS 1, , and W. B. WEHRENBERG 1

1 Biological Sciences Department, Purdue University Fort Wayne, Indiana 46805


Ovarian Dgr5-3beta-hydroxysteroid dehydrogenase (3beta-OH-SDH) and ovarian free and total cholesterol were determined in young (3 mo.) and aged (12-14 mo.) C57BL mice 18 days post-coitum (p.c.). There was less histochemically demonstrable 3beta-OH-SDH in the theca, granulosa and luteal cells and significantly more ovarian total cholesterol (1.85 vs 0.98 mg percent) in aged mice not maintaining pregnancy than in young animals. Females of either age successfully maintaining pregnancy to 18 days exhibited similar ovarian 3beta-OH-SDH activity and ovarian free and total cholesterol levels. The reduced enzyme activity in the older nonpregnant animal suggests a decrease in potential of the ovary to produce Dgr4-ketosteroids, while the elevation in total cholesterol may reflect a decline in conversion of cholesterol to steroid product.

Submitted on December 13, 1974
Accepted on April 28, 1975






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the Society for the Study of Reproduction.