Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by JOSSO, N.
Right arrow Articles by PICARD, J.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by JOSSO, N.
Right arrow Articles by PICARD, J.-Y.
Agricola
Right arrow Articles by JOSSO, N.
Right arrow Articles by PICARD, J.-Y.

Biology of Reproduction, Vol 13, 163-167, Copyright © 1975 by Society for the Study of Reproduction

Müllerian-Inhibiting Activity of Calf Fetal Testes: Relationship to Testosterone and Protein Synthesis

NATHALIE JOSSO 1, MAGUELONE G. FOREST 1, , and JEAN-YVES PICARD 1

1 Unité de Recherches de Génétique Médicale (I.N.S.E.R.M.) Hôpital des Enfants-Malades, 75730 PARIS Cedex 15, France


Müllerium-inhibiting activity was detected in incubation media of calf fetal testicular tissue. Dialysis of the medium did not modify its biological activity, but testosterone content of dialyzed medium was diminished by 92 percent. Four-fold concentration of incubation medium greatly enhanced its biological activity, which was destroyed by heat and blockage of sulphydryl groups by 0.5 M iodoacetic acid. Addition of cycloheximide to the medium during incubation decreased its biological activity, indicating that part of the activity is due to hormone newly synthesized during the incubation. These results prove that the anti-müllerian hormone is a macromolecule and suggest that it is probably a protein.

Submitted on March 5, 1975
Accepted on April 30, 1975






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the Society for the Study of Reproduction.