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Biology of Reproduction, Vol 13, 211-217, Copyright © 1975 by Society for the Study of Reproduction

Development of Two-cell Eggs Transferred into the Uteri of Ovariectomized Rats

JUNG-TSUNG WU 1

1 Worcester Foundation for Experimental Biology Shrewsbury, Massachusetts 01545


The possibility of 2-cell eggs developing into blastocysts in the uteri of ovariectomized rats was examined. Three and four days after transfer 14 and 32 percent of the recovered eggs were blastocysts, respectively. The development was either increased or decreased by treatment of the recipients with estrogen or progesterone, depending on the regimens used. Some of the blastocysts obtained developed into normal fetuses following their transfer into suitable recipients.

Examination of eggs at various times after transfer showed the occurrence of 1) binucleate and multinucleate cells, 2) two or more blastocysts or blastocyst-like structures inside a zona pellucida, and 3) large intracellular vesicles in cells of morulae. These suggest that the uterus may interfere with normal cellular interaction and embryonic organization.

 Submitted on March 28, 1975
Accepted on May 19, 1975






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Copyright © 1975 by the Society for the Study of Reproduction.