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Biology of Reproduction, Vol 13, 282-288, Copyright © 1975 by Society for the Study of Reproduction

Prostaglandins F in Uterine Tissue and Venous Plasma of Pseudopregnant Rats: Effect of Deciduomata

C. W. WEEMS 1, J. E. PEXTON 1, R. L. BUTCHER 1, , and E. K. INSKEEP 1

1 Division of Animal and Veterinary Science and Department of Obstetrics and Gynecology West Virginia University Morgantown, West Virginia 26506


Prostaglandins F (PGF) were measured in uterine tissue and venous plasma of 112 pseudopregnant rats in two experiments. Content and concentration of PGF in uterine tissue, measured on days 4, 6 and 9 through 13, increased from day 4 to 6 and were even higher on days 9 and 11 (P<0.01), but were lower on days 10 and 12. Concentration of PGF in uterine venous plasma, measured on days 6 and 9 through 14, was highest on day 9 (P<0.05) and higher on days 6, 9 and 11 (P<0.05) than on days 10, 12, 13 and 14. Progesterone in corpora lutea was greatest on day 6 and decreased through day 13 of normal pseudopregnancy.

To determine whether deciduomata inhibit secretion of PGF by the uterus, uterine tissue and venous plasma of 126 pseudopregnant rats with and without deciduomata were assayed for PGF in a third experiment. Samples were collected at 0600, 1200 and 1800 h on days 6, 9 and 12. Uterine concentration and content of PGF were consistently as high or higher in rats with deciduomal tissue than in control rats. Average concentration of PGF in uterine venous plasma was higher in rats with deciduomata (13.2 ng/ml) than in control rats (9.0 ng/ml). Progesterone in peripheral plasma was higher on day 9 than on days 6 or 12 in rats with deciduomal tissue. In control rats, plasma progesterone declined with day and was lower than in rats with deciduomal tissue except on day 6. In control rats and in those with deciduomal tissue, PGF was higher on day 9 than on day 6; progesterone was lower on day 9 than on day 6 in controls only. It is concluded that deciduomata prolong the functional life span of corpora lutea by some means other than inhibition of uterine secretion of PGF on days 6, 9 or 12 of pseudopregnancy.

 Submitted on March 17, 1975
Accepted on May 15, 1975






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Copyright © 1975 by the Society for the Study of Reproduction.