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Biology of Reproduction, Vol 13, 415-422, Copyright © 1975 by Society for the Study of Reproduction

Effects of Partial Lutectomy in PMSG-Primed Immature Pregnant Rats

K. M. NUTI 1, and R. K. MEYER 1

1 Department of Zoology University of Wisconsin Madison, Wisconsin 53706


Immature PMSG-primed female rats (8 IU PMSG at 30 days of age) were used to study the effects of reduced amounts of luteal tissue on pregnancy maintenance and serum progestins and gonadotropins. Pregnancy was maintained only to Day 12 when the number of corpora lutea (CL) was surgically reduced to four on Day 6. Either 2 mg progesterone or 1 IU prolactin daily between Days 6 and 18 maintained pregnancy in animals with four CL in situ. Serum levels of progesterone and 20agr-dihydroprogesterone in pregnant animals with four CL were significantly lower than in nonoperated controls between Days 8 and 12. Conversely, serum LH in animals with four CL was significantly higher than in control animals two days after lutectomy (Day 8 of pregnancy). FSH levels also tended to be slightly higher although this difference was not statistically significant.

A minimum of six CL was required for successful pregnancy maintenance in immature pregnant rats. Even though serum progestins were much lower than normal in animals with six CL, they were sufficient to ensure fetal survival and prevent termination of gestation. LH levels tended to be slightly elevated on Days 9 and 12 in animals with six CL although the increase was not significant. FSH levels in animals with six CL were significantly greater than controls.

The data suggest that steroid secretion by the full complement of CL in PMSG-treated immature pregnant rats exceeds the amounts required for the maintenance of pregnancy.

 Submitted on May 27, 1975
Accepted on July 17, 1975






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Copyright © 1975 by the Society for the Study of Reproduction.