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Biology of Reproduction, Vol 13, 541-545, Copyright © 1975 by Society for the Study of Reproduction
1 Reproductive Endocrinology Program,
Department of Pathology,
The University of Michigan,
Ann Arbor, Michigan 48104 Serum progesterone was measured by radioimmunoassay on Days 7, 9, 11, 13, 15, and 16 of
pregnancy in three groups of rats. 1) rats with two intact ovaries, 2) rats with one intact ovary
(unilaterally ovariectomized the evening of proestrus) and 3) rats with ectopic corpora lutea and a
single ovary from which in situ corpora lutea were removed on Day 6 of pregnancy. Progesterone
concentrations in the three groups were significantly different (P<0.05) from one another on each
day of pregnancy with the exception of Day 13 on which progesterone levels in groups 1 and 2
were not significantly different. Mean progesterone concentrations (ng/ml) and total luteal weights
(mg) on Day 16 were respectively 126 ng/ml, 59 mg (group 1), 68, 27 (group 2) and 28, 15 (group
3). A significant positive correlation (P<0.01; r = 0.97; n = 21) was found between total luteal
weight and serum progesterone concentration on Day 16 of pregnancy. These data indicate that the local environment of the ovary is not a prerequisite for the corpus
luteum to secrete physiological quantities of progesterone which are compatible with the
maintenance of pregnancy. The levels of progesterone in rats with ectopic corpora lutea are
reduced, but this appears to be largely attributable to the reduced quantity of luteal tissue, rather
than to a functional impairment.
Accepted on September 4, 1975
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