Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PETERSON, R. N.
Right arrow Articles by FREUND, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PETERSON, R. N.
Right arrow Articles by FREUND, M.
Agricola
Right arrow Articles by PETERSON, R. N.
Right arrow Articles by FREUND, M.

Biology of Reproduction, Vol 13, 552-556, Copyright © 1975 by Society for the Study of Reproduction

The Inhibition of the Motility of Human Spermatozoa by Various Pharmacologic Agents

RUDOLPH N. PETERSON 1, and MATTHEW FREUND 1

1 Laboratory of Reproductive Pharmacology, Department of Pharmacology, New York Medical College, Valhalla, New York 10595


A variety of drugs from different pharmacologic classes were tested for their effects on the motility of human spermatozoa. Most of the compounds tested inhibited sperm motility and a common mechanism of action for many of these agents was indicated by the observation that their inhibitory potency could be reduced by adenylic acid. From structure-activity relationships, the effect of these local anesthetic-like compounds on the fluorescence of the membrane probe-1-anilinonapthalene sulfonate (ANS), and their effects on metabolism, a mechanism of action, based on the bilayer couple hypothesis of drug-membrane interaction (Sheetz and Singer, 1974) is suggested.

Submitted on July 3, 1975
Accepted on September 9, 1975






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the Society for the Study of Reproduction.