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Biology of Reproduction, Vol 14, 248-252, Copyright © 1976 by Society for the Study of Reproduction

The Effect of Cocaine, Desipramine, 6-Hydroxydopamine and Indomethacin on the Sensitivity of the Estrogen-Dominated Ampulla of Rabbit Oviduct to (—)—Norepinephrine

A. JOHNS 1, and D. M. PATON 1

1 Department of Pharmacology, University of Alberta, Edmonton, Alberta T6G 2H7 Canada


The effect of the adrenergic innervation on the sensitivity of the ampullary portion of rabbit oviduct to (-)-norepinephrine has been examined. Tissues were removed from estrogen-dominated rabbits and isometric contractions of the longitudinal and circular muscle layers were recorded separately. Longitudinal muscle was significantly more sensitive to added (-)-norepinephrine than circular muscle. This difference in sensitivity was reduced by cocaine, desipramine and by 6-hydroxydopamine pretreatment. Blockade of extraneuronal uptake, of catechol-O-methyl transferase and of prostaglandin synthesis had no significant effect on the responses of either longitudinal or circular muscle to (-)-norepinephrine. It is suggested that the difference in sensitivity between the longitudinal and circular muscle layers of the ampulla to (-)-norepinephrine is due to a greater concentration of adrenergic nerves present in the circular muscle layer.

Note:
ACKNOWLEDGMENTS This study was supported by research grants from the World Health Organization and the Medical Research Council of Canada (MT 2472). We should like to thank Mrs. A. Barkai and Mrs. P. Lauzon for their careful technical assistance. Desipramine and U0521 were generously donated by Geigy Canada Ltd. and Upjohn Co. Canada, respectively.

Submitted on August 28, 1975
Accepted on October 14, 1975






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Copyright © 1976 by the Society for the Study of Reproduction.