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Biology of Reproduction, Vol 14, 401-404, Copyright © 1976 by Society for the Study of Reproduction

Induction of Ovulation in Premenarchial Rhesus Monkeys with Human Gonadotropins

GERSON WEISS 1, IRA RIFKIN 1, , and LINDA E. ATKINSON 1

1 Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016 and The Population Council, Biomedical Division, Rockefeller University, New York, New York 10021


Five premenarchial rhesus monkeys were treated with human menopausal gonadotropin (HMG) and chorionic gonadotropin (HCG) to induce ovulation. All animals had large elevations in serum estradiol concentrations and perineal sex skin development in response to HMG injections. Four of five monkeys had peripheral progesterone concentrations suggestive of ovulation after HCG administration and corpora lutea were confirmed histologically in two animals. Thus, ovaries of reproductively immature monkeys are capable of steroid secretion and ovulation when provided with sufficient gonadotropin stimulation.

Note:
ACKNOWLEDGMENT The authors wish to thank Dr. M. R. Bahgat, Mr. R. Sanchez and the staff of the Population Council primate colony for their assistance.

Submitted on October 8, 1975
Accepted on December 9, 1975






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Copyright © 1976 by the Society for the Study of Reproduction.