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Biology of Reproduction, Vol 14, 641-650, Copyright © 1976 by Society for the Study of Reproduction

Response of the Sertoli Cell and Stem Germ Cell to 6 0Co ggr-Radiation (Dose and Dose Rate) in Testes of Immature Rats

B. H. ERICKSON 1, and M. J. BLEND 1

1 Comparative Animal Research Lab oratory, Oak Ridge, Tennessee 37830


We examined ggr-radiation effects (dose and dose rate) on the Sertoli cells and stem cells of the germinal line in immature rat testes. Prior to Day 4 of postnatal development, the gonocyte or primitive germ cell was the most radiosensitive cell in the testis. From Day 4 to approximately Day 15 the Sertoli cell was the most critical element, and thereafter the stem cell was of first importance. A dose of 100 rads irreversibly reduced the number of Sertoli cells to 63 percent of control. Of the ages tested beyond Day 2, the 9-day testis was most severely affected. We estimated that a dose of 400 rads would reduce sperm output of the 9-day testis to 21 percent of control. After Day 4 and prior to Day 20, 300 rads produced a permanent decrement in the stem-cell population. Six hundred rads are required to produce this effect in the adult. Dose rate was an important mediator of the radioresponse of both Sertoli and germ cells.

Submitted on October 21, 1975
Accepted on February 23, 1976




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Copyright © 1976 by the Society for the Study of Reproduction.