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Biology of Reproduction, Vol 14, 658-664, Copyright © 1976 by Society for the Study of Reproduction

Utero-Oviductal Motility, Egg Transport and Implantation in Prostaglandin Treated Rabbits

I. AREF 1, and E. S. E. HAFEZ 1

1 Reproductive Physiology Laboratories, C. S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201


In vivo utero-oviductal motility, egg transport in the oviduct and implantation were studied in rabbits following vaginal administration of silastic suppositories containing 1 mg of PGE2 or PGF2agr. Utero-oviductal motility was also monitored following intraoviductal or intrauterine instillation of PGE2 or PGF2agr. Immediate inhibition or stimulation of oviductal motility followed instillation of microdoses of PGE or PGF2agr in the lumen of the oviduct. Intrauterine instillation of microdoses of prostaglandins was followed by immediate and intensive stimulation of myometrial contractility. The oviduct responded to intrauterine prostaglandins in a few cases. Prolonged responses followed intravaginal administration of prostaglandin in suppositories. When administered at 24 h post coitum, PGF2agr vaginal suppositories were effective in modifying egg transport and implantation. Efficacy of PGF2agr to prevent implantation decreased when the suppositories were administered at 4 days post coitum. Vaginal administration of PGE2 at 24 h post coitum failed to modify egg transport or implantation. PGE2 vaginal suppositories were effective in preventing implantation when administered at 4 days post coitum. The regimen may offer an approach for post ovulatory contraception or menstrual induction in women.

Note:
ACKNOWLEDGMENTS This research was supported by Ford Foundation Grant 710-0287A. Thanks are due to Dr. J. Pike, Upjohn Company, Kalamazoo, Michigan, for the generous supply of prostaglandins, and for Dr. H. S. Maia for donating the recording baloons.

Submitted on November 17, 1975
Accepted on February 27, 1976






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Copyright © 1976 by the Society for the Study of Reproduction.