Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 15, 134-139, Copyright © 1976 by Society for the Study of Reproduction

Prostaglandin F2agr Receptors in Bovine Corpora Lutea Throughout Pregnancy

Ch. V. RAO 1

1 Departments of Obstetrics-Gynecology and Biochemistry, University of Louisville, School of Medicine, Louisville, Kentucky 40202


These studies were undertaken to examine whether or not receptors for prostaglandin PGF2agr were present in bovine corpora lutea throughout pregnancy. The results show that cell membranes prepared from corpora lutea throughout pregnancy bind 3H-PGF2agr reflecting the availability of its receptors. Variations in the receptor numbers rather than in the receptor affinities appear to account for the variations in 3H-PGF2agr binding throughout pregnancy. The fact that PGF2agr receptors are present in corpora lutea throughout pregnancy and yet luteolysis occurs only at the end of pregnancy suggests that PGF2agr receptor availability is not a limiting factor in the onset of luteolysis.

Note:
ACKNOWLEDGMENTS The excellent technical assistance of Mr. Fred Carman, Jr., throughout these studies and of Mr. Jim Reynolds and Paul Kelty in a portion of this work is gratefully acknowledged.

Submitted on March 4, 1976
Accepted on April 6, 1976






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Copyright © 1976 by the Society for the Study of Reproduction.