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Biology of Reproduction, Vol 15, 147-152, Copyright © 1976 by Society for the Study of Reproduction

Serum FSH, LH, and Prolactin in Adult Ovariectomized Mice Bearing Silastic Implants of Estradiol: Responses to Social Cues

F. H. BRONSON 1

1 The Institute of Reproductive Biology, Department of Zoology, University of Texas Austin, Texas 78712


The objective of these experiments was to examine the usefulness of estradiol-implanted, ovariectomized female mice for studies of gonadotropic responses to social cues. A 13-point dose response curve examined the relationship between implanted estradiol (in silastic capsules) and serum concentrations of FSH, LH, and prolactin in adult, ovariectomized, CF-1 females. This wide range of doses yielded a) all of the variation in serum LH that is normally present during the estrous cycle of the intact female but b) failed to yield the high levels of prolactin that occur during the intact female’s peri-ovulatory period and c) failed to suppress serum FSH levels to concentrations characteristic of any stage of the estrous cycle. In a second set of experiments, ovariectomized females were implanted with one of two doses of estradiol and then either housed in isolation, isolated and exposed to the odor of male urine, or grouped six per cage. Females implanted with the high dose of estradiol showed no significant effects of such housing procedures on serum gonadotropins. Females bearing the low dose of estradiol, however, responded to male urine with a marked elevation in serum LH (no effect on FSH or prolactin) and responded to grouping with elevated prolactin and suppressed LH levels (again no effect on FSH), all when compared to isolated controls. Thus, ovariectomized females bearing the low dose implant of estradiol seem to be normally responsive to social cues despite their abnormal serum gonadotropin levels.

Submitted on February 4, 1976
Accepted on April 12, 1976




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Copyright © 1976 by the Society for the Study of Reproduction.