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Biology of Reproduction, Vol 15, 168-172, Copyright © 1976 by Society for the Study of Reproduction

Age and Sex Differences in Prolactin Response to Phenothiazines in Rats

H. G. BOHNET 1, C. ARAGONA 1, , and H. C. FRIESEN 1

1 Department of Physiology, University of Manitoba, 770 Bannatyne Avenue Winnipeg, Manitoba


Possible changes in response of the hypothalamo-pituitary prolactin (PRL) axis to long acting (fluphenazine enanthate; FPZ) and short acting (chlorpromazine; CPZ) phenothiazine derivatives were investigated in male and female rats at different stages of maturation. Maximal serum PRL concentrations after CPZ were not different in male rats aged 20, 40 or 60 days (130 ng/ml). Serum PRL levels were elevated for 3 h in the prepubertal and pubertal males and for 4 h in adult rats. The decline of PRL was most rapid in the youngest rats, and slowest in the 60 day old males. In females, maximal serum PRL concentrations after CPZ were 2 to 3 times higher in 40 and 60 day old rats than in 20 day old animals (100 ng/ml). The decline in serum PRL in female rats again was most rapid in younger rats. The elevation of PRL lasted as long as 4 h in all age groups. Ten days after FPZ serum PRL was not increased in prepubertal rats, but still was twice as high in peripubertal and adult animals as compared to control values in both sexes prior to treatment. These studies indicate significant age and sex differences in PRL response after phenothiazines and these variations must be taken into account when using this drug to maintain elevated serum prolactin levels.

Note:
ACKNOWLEDGMENTS The studies were supported by research grants from the Medical Research Council of Canada and the USPHS Child Health and Human Development Institute No. HD 07843-03. We thank the NIH for supply of the radioimmunoassay kits for rPRL. We are indebted to Mr. Jeffry Harris for the preparation of the figures and to Mrs. C. Froese for typing the manuscript.

Submitted on January 1, 1976
Accepted on April 15, 1976




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[Abstract] [PDF]


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Copyright © 1976 by the Society for the Study of Reproduction.