Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 15, 228-234, Copyright © 1976 by Society for the Study of Reproduction

Steroid Metabolism by Fetal and Neonatal Rat Reproductive Tracts

CHHANDA GUPTA 1, and ERIC BLOCH 1

1 Departments of Gynecology and Obstetrics and Biochemistry, and the Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10461


The metabolism of labeled progesterone, pregnenolone, and dehydroepiandrosterone and its sulfate by genital tracts of fetal and newborn rats explanted into culture medium or during incubation as homogenates, was studied. Genital ducts of 16.5 and 20.5 day old male fetuses and of male newborns reduced progesterone to 5agr-pregnane-3,20-dione and 3agr-hydroxy-5agr-pregnan-20-one. Newborn but not fetal ducts converted pregnenolone to pregnanedione. Dehydroepiandrosterone sulfate was metabolized to the free alcohol and to 5-androstene-3beta, 17beta-diol by genital ducts of 16.5 day male fetuses and both male and female newborns. Steroid reductase and sulfatase activity was similar in ductal as in control tissues (liver, lung, kidney). Conversion of C2 1 to C1 9 steroids was not found. The results demonstrate a capacity of genital tracts of perinatal rats for reductive metabolism of progesterone, for steroid sulfatase activity, and confirm the capacity for reduction of the 17-keto group of dehydroepiandrosterone.

Note:
ACKNOWLEDGMENTS The technical assistance of Mr. Sion Mohaber is gratefully acknowledged.

Submitted on March 10, 1976
Accepted on April 26, 1976






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Copyright © 1976 by the Society for the Study of Reproduction.