Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by TILLSON, S. A.
Right arrow Articles by NEILL, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TILLSON, S. A.
Right arrow Articles by NEILL, J. D.
Agricola
Right arrow Articles by TILLSON, S. A.
Right arrow Articles by NEILL, J. D.

Biology of Reproduction, Vol 15, 291-296, Copyright © 1976 by Society for the Study of Reproduction

Interrelationships Between Pituitary Gonadotrophins and Ovarian Steroids in Baboons During Continuous Intrauterine Progesterone Treatment

S. A. TILLSON 1, D. A. SWISHER 1, B. B. PHARRISS 1, R. E. ERICKSON 1, , and J. D. NEILL 1

1 ALZA Research, 950 Page Mill Road, Palo Alto, California 94304 and Dept. Physiology, Emory University, Atlanta, Georgia


This study was designed to investigate possible menstrual cycle alterations brought about by an intrauterine device or by contraceptive levels of localized intrauterine progesterone in baboons.

In one group of baboons having either an Intrauterine Progesterone Contraceptive System (IPCS) releasing 65 µg progesterone/day or a Lippes Loop in place, plasma luteinizing hormone (LH), follicle stimulating hormone (FSH). progesterone (P), and estradiol 17beta (E2) were measured by radioimmunoassay during the menstrual cycle.

In another group, only progesterone and estradiol were assayed to detect any quantitative difference in plasma progesterone with the two contraceptives.

Results indicated no significant differences in hormone levels between control, Lippes Loop, or IPCS treated cycles. An apparent increase in plasma progesterone while the Lippes Loop was in place was not statistically significant.

Note:
ACKNOWLEDGMENTS The authors gratefully acknowledge Dr. V. C. Stevens for his generous gift of baboon LH and FSH standards and Dr. L. Gordon for statistical advice.

Submitted on January 31, 1976
Accepted on April 22, 1976






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by the Society for the Study of Reproduction.