Biol Reprod Lalor Postdoctoral Fellowships -- Application Deadline January 15, 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LINDLOFF, G.
Right arrow Articles by SMIDT, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LINDLOFF, G.
Right arrow Articles by SMIDT, D.
Agricola
Right arrow Articles by LINDLOFF, G.
Right arrow Articles by SMIDT, D.

Biology of Reproduction, Vol 15, 303-310, Copyright © 1976 by Society for the Study of Reproduction

The Effect of Prostaglandin F2agr on Corpus Luteum Function in the Göttingen Miniature Pig

G. LINDLOFF 1, W. HOLTZ 1, F. ELSAESSER 1, K. KREIKENBAUM 1, , and D. SMIDT 1

1 Institut für Tierzucht und Haustiergenetik and Abteilung für Klinische und Experimentelle Endokrinologie der Universitäts-Frauenklinik, Göttingen University, 3400 Göittingen, West Germany


The effect of intrauterine (iu) application of PG (Prostaglandin F2agr-tromethamine salt, Upjohn) on cycle length, progesterone and LH levels in the cycling miniature sow (Göttingen strain) has been investigated.

Cycle length was significantly reduced by 2.0-2.1 days when PG-application occurred on Day 13 of the cycle (Day 1 = 1st day of standing heat). PG application on Day 7, 11 or 12 did not elicit a similar response, nor did the iu infusion of saline on Day 13. Pretreatment with estradiol-benzoate had no effect on the action of PG or control treatment. Injection of PG into each corpus luteum (200 µg dissolved in .1 ml saline/CL) rendered results which were identical with those obtained by iu infusion, indicating that the lack of response to PG before Day 13 is not because of the absence of a transport mechanism acting between uterus and ovary.

Progesterone levels tended to be temporarily increased with rapid iu infusion of PG both on Days 7 and 13 of the cycle. Two hours after PG-infusion on Day 13, progesterone levels started to fall, dropping to basal levels within 56 h. A drop in progesterone on Days 8 and 9 following treatment on Day 7 was a result of the halothane anesthesia.

No direct effect of PG on LH release by the pituitary was observed. There was some indication of a stress dependent increase in LH prior to surgery and a slight depression of both mean LH level and spontaneous spiking activity under halothane anesthesia in individual cases.

Note:
ACKNOWLEDGMENTS The authors are grateful to Mrs. J. Ebeling, Mrs. I. Rippen, Miss A. Walli, Mr. S. Büyükhatipoglu and Mr. O. Dörl for valuable technical assistance and Dr. E. Bruns for his assistance with the statistical analyses. We want to thank Dr. J. W. Lauderdale from the Upjohn Company, Kalamazoo, Michigan for supplying the prostaglandin, Dr. G. D. Niswender from the Department of Physiology and Biophysics, Colorado State University at Fort Collins, Colorado and Dr. L. E. Reichert from the Department of Biochemistry, Emory University at Atlanta Georgia for supplying the antiserum and the LH standard preparation respectively. This research was supported by the Deutsche Forschungsgemeinschaft.

Submitted on January 27, 1976
Accepted on May 3, 1976






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by the Society for the Study of Reproduction.