Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DONAHOE, P. K.
Right arrow Articles by HENDREN, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DONAHOE, P. K.
Right arrow Articles by HENDREN, W. H., III
Agricola
Right arrow Articles by DONAHOE, P. K.
Right arrow Articles by HENDREN, W. H.

Biology of Reproduction, Vol 15, 329-334, Copyright © 1976 by Society for the Study of Reproduction

The Production of Mullerian Inhibiting Substance by the Fetal, Neonatal and Adult Rat

PATRICIA K. DONAHOE 1, YASUO ITO 1, SUDIR MARFATIA 1, , and W. HARDY HENDREN III 1

1 From the Division of Pediatric Surgery and the Pediatric Surgical Research Laboratory, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114


The secretory pattern of Mullerian Inhibiting Substance in the rat was documented by a graded organ culture assay on each day of the perinatal period and at more widely spaced intervals in the adult period. The influence of placenta and pituitary on Mullerian Inhibiting Substance production was studied. Fetal testicular fragments were displaced from target Mullerian ducts to determine if Mullerian Inhibiting Substance would act at a distance.

Rat testes produced Mullerian Inhibiting Substance throughout the latter third of gestation. Its production continued during the first three weeks of extrauterine life, after which it disappeared, coincident with weaning. Hypophysectomy carried out after 20 days of age was ineffective in restoring Mullerian Inhibiting Substance activity to the adult rat testis. Placental fragments neither prolonged nor enhanced the Mullerian Inhibiting Substance activity of perinatal testes in organ culture. Mullerian Inhibiting Substance exerted its regressive effect on Mullerian ducts placed at a distance from a testicular source.

Note:
ACKNOWLEDGMENT The authors acknowledge helpful discussions and continued interest of John F. Enders, John D. Crawford, David A. Swann, and J. Micheal Price.

Submitted on March 2, 1976
Accepted on May 17, 1976




This article has been cited by other articles:


Home page
 J AndrolHome page
X. Wu, S. Wan, S. Pujar, M. E. Haskins, D. H. Schlafer, M. M. Lee, and V. N. Meyers-Wallen
A Single Base Pair Mutation Encoding a Premature Stop Codon in the MIS Type II Receptor Is Responsible for Canine Persistent Mullerian Duct Syndrome
J Androl, January 1, 2009; 30(1): 46 - 56.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. P. Szotek, R. Pieretti-Vanmarcke, P. T. Masiakos, D. M. Dinulescu, D. Connolly, R. Foster, D. Dombkowski, F. Preffer, D. T. MacLaughlin, and P. K. Donahoe
Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness
PNAS, July 25, 2006; 103(30): 11154 - 11159.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Teixeira, S. Maheswaran, and P. K. Donahoe
Mullerian Inhibiting Substance: An Instructive Developmental Hormone with Diagnostic and Possible Therapeutic Applications
Endocr. Rev., October 1, 2001; 22(5): 657 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Watanabe, T. R. Clarke, A. H. Lane, X. Wang, and P. K. Donahoe
Endogenous expression of Mullerian inhibiting substance in early postnatal rat Sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites
PNAS, February 15, 2000; 97(4): 1624 - 1629.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
V. Rouiller-Fabre, S. Carmona, R. A. Merhi, R. Cate, R. Habert, and B. Vigier
Effect of Anti-Mullerian Hormone on Sertoli and Leydig Cell Functions in Fetal and Immature Rats
Endocrinology, March 1, 1998; 139(3): 1213 - 1220.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by the Society for the Study of Reproduction.