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Biology of Reproduction, Vol 15, 366-374, Copyright © 1976 by Society for the Study of Reproduction
1 Department of Psychology,
University of California,
Berkeley, California Lesions of the suprachiasmatic nuclei (SCN) of golden hamsters prevented the testicular
regression ordinarily observed in short photoperiods or after peripheral enucleation. These lesions
also induced testicular regrowth in hamsters whose testes had previously been regressed by the
absence of adequate photostimulation. Interruption of the primary optic tracts just caudal to the
chiasm did not prevent testicular regression by short photoperiods. We hypothesize that testicular
responses to photoperiod are mediated by the retinohypothalamic tract, which projects to the
SCN, and that the SCN in turn control the secretion of a pineal antigonadal substance. The
mechanism for this control may involve entrainment by light of hormonal rhythms in the pineal
that are regulated by the SCN. Alternatives to this hypothesis are discussed.
Note:
ACKNOWLEDGMENTS
This research was funded by NICHD Grant HD-02982 to Irving Zucker. LPM was supported by
NICHHD postdoctoral fellowship F22-HD-01 39102.
We thank Dr. I. Zucker for helpful criticisms of the
experiment and manuscript and Ms. M. R. Roisman
for typing the manuscript.
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