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Biology of Reproduction, Vol 15, 497-503, Copyright © 1976 by Society for the Study of Reproduction

Luteotrophic Action of Decidual Tissue in the Rat: Comparison of Jugular and Uterine Vein Progesterone Levels, and the Effect of Ligation of the Utero-Ovarian Connections

V. DANIEL CASTRACANE 1, and I. ROTHCHILD 1

1 Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106


One of the purposes of these experiments was to determine whether the previously reported luteotrophic effect of decidual tissue (DT) in the rat could have been due to the secretion of progesterone by the DT. A comparison of the progesterone levels in the uterine and jugular vein blood of DT-bearing pseudopregnant rats, however, failed to reveal any significant difference between them. These comparisons were made on both Day 8 and Day 10 of pseudopregnancy in otherwise untreated DT-bearing rats, and 24 h after an injection of 2-Br-agr-ergocryptine (CB-154) (to suppress prolactin secretion) on Day 9, in another group of DT-bearing rats; under these conditions the peripheral serum progesterone concentration has been found to be significantly higher in DT-bearing than in hysterectomized pseudopregnant rats.

The other experiments were undertaken to determine whether the ability of DT to protect the corpora lutea against ergot-induced depression of prolactin secretion was dependent on a local utero-ovarian relationship. Ligation and severing of the oviducts, and/or the utero-ovarian vasculature, in one experiment, and the presence of a single DT-bearing uterine horn contralateral to a single remaining ovary, in another, did not interfere with this expression of the luteotrophic action of the DT.

These results support the concept of a luteotrophic action of DT, and imply that this action is exerted "hormonally."

Note:
ACKNOWLEDGMENTS We thank Helen Wilk and Edward Butler for their help in care of the animals, Paula Hoos and Ellen O’Laughlin-Phillips for the progesterone assays, Rosa Garnett for secretarial assistance, Dr. G. D. Niswender for the gift of progesterone antiserum #337, and Mr. Siegfried S. Wahrman of Sandoz Pharmaceuticals, E. Hanover, New Jersey, for the gift of ergocomine free base, and 2-Br-agr-ergocryptine (CB-154).

Submitted on May 12, 1976
Accepted on July 1, 1976






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Copyright © 1976 by the Society for the Study of Reproduction.