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Biology of Reproduction, Vol 15, 704-713, Copyright © 1976 by Society for the Study of Reproduction

Immunological Evidence of Uteroglobin (Blastokinin) in the Male Reproductive Tract and in Nonreproductive Ductal Tissues and Their Secretions

I. G. NOSKE 1, and M. FEIGELSON 1

1 Departments of Obstetrics and Gynecology and of Biochemistry, College of Physicians and Surgeons, Columbia University, Roosevelt Hospital, New York, New York 10019


Uteroglobulin (blastokinin) has been thought to be localized in the female reproductive tract, where it has been presumed to play a significant role in preimplantation events during early pregnancy. Employing two antisera in three test systems, immunological evidence now demonstrates the presence of the uteroglobin antigen in the male genital tract of the rabbit, viz., in vas deferens tissue extracts and secretions, cauda epididymal extracts and seminal plasma. Furthermore, components of the male and female reproductive tracts of the human, viz., seminal plasma and progestational endometrial extracts and uterine and oviducal secretions, contain proteins which cross-react with identity with anti-rabbit uteroglobin. Uteroglobin is undetectable in serum and in all rabbit non-reproductive tissue extracts in which it was sought, with the exception of two organ systems comprised of ductal structures, the respiratory and digestive tracts. Rabbit tracheal, bronchial and lung tissue extracts and secretions, esophageal tissue extracts and secretions and jejunal secretions, all contain an antigen indistinguishable from and presumably identical to uteroglobin. Thus, uteroglobin is not exclusively a female reproductive tract protein; it is also present in the male genital tract of both rabbit and human and in certain nonreproductive tissues and their secretions. These findings broaden the scope of possible biological functions of this protein, beyond events within the uterus during early pregnancy.

Note:
ACKNOWLEDGMENTS This research was supported by NIH Grant No. HD-05116. We thank Dr. D. Crawford of Roosevelt Hospital, Dept. Obstetrics and Gynecology, for providing the human material and Dr. F. Margolis of Roche Institute of Molecular Biology, Nutley, N.J. for his assistance in elaborating the antibody. The skillful technical assistance of Mrs. E. Scott is gratefully acknowledged.

Submitted on June 15, 1976
Accepted on August 26, 1976




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[Abstract] [Full Text] [PDF]


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Copyright © 1976 by the Society for the Study of Reproduction.