Biol Reprod Keystone Symposia Conference on Frontiers in Reproductive Biology & Regulation of Fertility.
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Biology of Reproduction, Vol 16, 1-17, Copyright © 1977 by Society for the Study of Reproduction

The Role of Cyclic AMP in the Regulation of Smooth Muscle Cell Contraction in the Uterus

STANLEY G. KORENMAN 1, and J. FREDERICK KRALL 1

1 Molecular Endocrinology Laboratory, Veterans Administration Hospital, Sepulveda, California and Department of Medicine, San Fernando Valley Medical Program, University of California, Los Angeles, California


The complex patterns of uterine motility reflect the interaction of a number of active compounds. Many of these agents have been shown to interact with the beta-adrenergic catecholamine-stimulable adenylate cyclase system to alter cAMP levels in the smooth muscle layers of the uterus. From the recognized mechanism of action of cAMP, any change in the concentration of the cyclic nucleotide should lead to change in the activity of cAMP-dependent protein kinase and as a result a change in the activity of phosphoproteins which function at a still more fundamental level to regulate muscle cell contractility. Treatment of the rat myometrium with beta-adrenergic agonist results in an increase in protein kinase activity associated with cellular membranes and increased ATP-dependent Ca++-transport by these same membranes. The ability of cAMP to duplicate the effects of beta-agonist stimulation in cell free membrane preparations suggests adrenergic control of smooth muscle cell function and hence myometrial contractility occurs by altering the distribution of intracellular Ca++ between bound and free pools.

Note:
ACKNOWLEDGMENTS Investigations reported here were supported by NIH grant HD-09285 and by Research and Education Funds from the Veterans Administration. The authors gratefully acknowledge the technical assistance of Mr. Abbott M. Schindler and Ms. Janet L. Swensen.




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Copyright © 1977 by the Society for the Study of Reproduction.