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Biology of Reproduction, Vol 16, 238-243, Copyright © 1977 by Society for the Study of Reproduction
1 Division of Pediatric Surgery and Pediatric Surgical Research Laboratory,
Massachusetts General Hospital, and the Department of Surgery,
Harvard Medical School, Boston, and the Department of Anatomy,
University of Massachusetts Medical School,
Worcester, Massachusetts A graded organ culture assay was used to detect Müllerian Inhibiting Substance activity in
bovine testes. Müllerian Inhibiting Substance was present in all fetuses available for study from Day
110 to Day 210 of gestation. The assay detected similarly high activity during the first six weeks
after birth. At eight weeks, activity was still present but diminished. Loss of activity, as in the rat,
appeared to coincide with the time of weaning. Electron microscopic studies of the neonate calf
testes demonstrate highly active Sertoli cells with a morphology suggestive of a protein secreting
cell, and implicate the Sertoli cell as the source of Müllerian Inhibiting Substance. The neonate calf
testes should be an excellent source of material for the isolation and biochemical characterization
of Müllerian Inhibiting Substance.
Note:
ACKNOWLEDGMENTS
We appreciate the help of David A. Swann, Ph.D.,
Inez Beitans, M.D., and John Crawford, M.D. We
acknowledge the technical assistance of Carmelo
Bondi and Thomas Manganaro and the secretarial
assistance of Margaret Doherty.
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