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Biology of Reproduction, Vol 17, 304-308, Copyright © 1977 by Society for the Study of Reproduction

Ovarian Function in the Preovulatory Rabbit

CHUNG H. WU 1, LUIS BLASCO 1, GEORGE L. FLICKINGER 1, , and GEORGE MIKHAIL 1

1 Endocrine Section, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104


Ovarian secretion of hormones was determined at hourly intervals for a period of 9 h following the administration of human chorionic gonadotropin (hCG) to estrous rabbits. Blood flow to the ovary was measured with radio-labeled microspheres immediately before peripheral and ovarian vein blood samples were obtained. The ovarian vein plasma concentration and secretion rates of estradiol-17beta (E2) and testosterone (T) rose sharply at the 2 h period. By 4 h, when ovarian blood flow reached its maximum, the secretion rate of E2 and T reached a second peak. Secretion rates of estrone (E1), androstenedione (A), progesterone (P) and 20agr-dihydroprogesterone (20agr-OH-P) showed only a single peak at the 4 h period. There was no significant change in the peripheral blood levels of E1, E2 and A and there was a small rise in T between the second and fourth hours; in contrast, an increase in P noted in the first hour was sustained up to the eighth hour, while 20agr-OH-P was elevated throughout with peaks at 2, 5 and 9 h.

In spite of the maximum peripheral levels of hCG in the first hour, peak hCG "removal rate" by the ovary occurred an hour later. hCG seems to stimulate ovarian steroidogenesis, which is further augmented by increased ovarian uptake of hCG. The data also suggests that the significant but brief rise in E2 and T production serves an intraovarian rather than a systemic function.

Note:
ACKNOWLEDGMENT Materials for radioimmunoassay of LH were generously provided by the National Pituitary Agency and Endocrinology Study Section, National Institutes of Health. Technical assistance of Mrs. Judith Wang and Mr. Robert Krill is gratefully acknowledged.

Submitted on February 10, 1977
Accepted on April 26, 1977




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Copyright © 1977 by the Society for the Study of Reproduction.