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Biology of Reproduction, Vol 18, 118-124, Copyright © 1978 by Society for the Study of Reproduction

Serum Gonadotropin Levels in the Ovariectomized Rabbit: Effect of Acute and Chronic Administration of Estradiol

L. DUFY-BARBE 1, B. DUFY 1, , and J. D. VINCENT 1

1 Laboratoire de Neurophysiologie, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux, France


Long term ovariectomized (OVX) rabbits were treated with estradiol: acutely by single injections of estradiol benzoate (EB) i.m. or i.v. and chronically by s.c. implantation of silastic capsules containing crystalline estradiol-17beta (E2).

A single injection of EB induced, within hours, a decrease in both LH and FSH levels. Serum LH and FSH were depressed following implantation of E2. The patterns of the two gonadotropin responses differed in that estrogen administration was able to decrease LH levels to precastration values while FSH levels remained significantly higher, regardless of dose or route of administration used. This finding suggests that in the female rabbit estradiol plays a major role in the negative feedback control of LH secretion while another factor may be required for regulating FSH.

In addition, the ability of estrogen to stimulate LH secretion was tested in E2-implanted OVX does: only 2 of 8 animals responded to a single injection of EB by a monophasic LH peak with no correspondent change in FSH. These results suggest that E2-implanted OVX does may not provide a suitable model for studying the stimulatory effect of estrogen on LH secretion.

Note:
ACKNOWLEDGMENTS The technical help of J. Arsaut, M. Cazalis and R. Miguelez is acknowledged. The authors wish to thank J. C. Hendrick and P. Franchimont who provided the antiserum used for FSH determinations and the NIAMDD for the rat pituitary hormones. The authors are grateful to Dr. W. D. Peckham (Department of Physiology, University of Pittsburgh) for his generous assistance in the preparation of this manuscript. This work was supported by grant no. 74.7.0516 from the Delegation Generale a la Recherche Scientifique et Technique and CRAT No. 74-1:455-35 from INSERM.

Submitted on February 11, 1977
Accepted on July 26, 1977






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Copyright © 1978 by the Society for the Study of Reproduction.