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Biology of Reproduction, Vol 18, 198-203, Copyright © 1978 by Society for the Study of Reproduction

Effects of Drugs That Modify Brain Monoamine Concentrations on Photoperiodically-Induced Testicular Growth in Coturnix Quail (Coturnix coturnix japonica)

M. E. EL HALAWANI 1, W. H. BURKE 1, , and L. A. OGREN 1

1 Department of Animal Science, University of Minnesota, St. Paul, Minnesota 55108


The monoamine oxidase inhibitor tranylcypromine (TCP) increases brain dopamine (DA), norepinephrine (NE) and serotonin (5-HT) levels and inhibits photoperiodically-induced testicular growth in quail. Blockade of catecholamine synthesis by agr-methyl-tyrosine (MT) in TCP treated quail preferentially elevates 5-HT levels and does not interfere with TCP inhibition of the gonads, however, treatment with parachlorophenylalanine (PCPA) reduces 5-HT and DA and antagonizes the action of TCP. Treatment with PCPA alone causes further augmentation of testicular response to photostimulation and reduces 5-HT and DA levels in the brain, whereas 5-hydroxytryptophan (5-HTP) administration elevates central 5-HT stores and partially inhibits testicular development.

The results are consistent with the view that 5-HT may have an inhibitory effect on the process of gonadal development; in addition, an inhibitory influence of DA may also be involved.

Submitted on May 18, 1977
Accepted on August 20, 1977




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Copyright © 1978 by the Society for the Study of Reproduction.