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Biology of Reproduction, Vol 18, 198-203, Copyright © 1978 by Society for the Study of Reproduction
1 Department of Animal Science,
University of Minnesota,
St. Paul, Minnesota 55108 The monoamine oxidase inhibitor tranylcypromine (TCP) increases brain dopamine (DA),
norepinephrine (NE) and serotonin (5-HT) levels and inhibits photoperiodically-induced testicular
growth in quail. Blockade of catecholamine synthesis by The results are consistent with the view that 5-HT may have an inhibitory effect on the process
of gonadal development; in addition, an inhibitory influence of DA may also be involved.
-methyl-tyrosine (MT) in TCP treated
quail preferentially elevates 5-HT levels and does not interfere with TCP inhibition of the gonads,
however, treatment with parachlorophenylalanine (PCPA) reduces 5-HT and DA and antagonizes
the action of TCP. Treatment with PCPA alone causes further augmentation of testicular response
to photostimulation and reduces 5-HT and DA levels in the brain, whereas 5-hydroxytryptophan
(5-HTP) administration elevates central 5-HT stores and partially inhibits testicular development.
Accepted on August 20, 1977
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