Biol Reprod 2009 SSR Annual Meeting Abstracts
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Biology of Reproduction, Vol 18, 459-467, Copyright © 1978 by Society for the Study of Reproduction

Effects of Canine Fetal Testes and Testicular Tumors on Müllerian Ducts

REGINE PICON 1, LUC PICON 1, STEPHANE CHAFFAUX 1, , and ALAIN KTORZA 1

1 Laboratoire de Physiologie du Developpement, Universite Paris VII, 2 Place Jussieu, 75005 Paris


The effects of canine fetal and adult testes and testicular tumors on reproductive tracts from 14.5 day old rat fetuses cultured in vitro were investigated. Müllerian inhibiting activity (MIA) was found in fetal canine testes, confirming the lack of species specificity of the Müllerian inhibiting substance. Adult testes and testicular tumors were unable to produce regression of Müllerian ducts. The disappearance of the MIA in the adult testes in vitro contrasted with an active secretion of testosterone. The absence of the MIA in the testicular tumors, including sertolinomas is discussed.

Note:
ACKNOWLEDGMENTS We are indebted to Mrs. M. N. Gangnerau for technical assistance and to the Delegation Generale a la Recherche Scientifique et Technique (Grant No. 75-7-1312) for financial support.

Submitted on August 3, 1977
Accepted on September 30, 1977






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Copyright © 1978 by the Society for the Study of Reproduction.