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Biology of Reproduction, Vol 19, 202-211, Copyright © 1978 by Society for the Study of Reproduction
1 Animal Research Institute,
Reproductive Physiology Program,
Ottawa, Ontario, Canada K1A 0C6 The concentration of the unconjugated and sulfoconjugated estrogens have been measured
in the fetal and maternal fluids of the ewe throughout pregnancy. Estrone sulfate was the major estrogen in all the fluids examined. In the fetal fluids, it was first
detectable in allantoic fluid on Day 31, peaked at a high level (14.2 ng/ml) on Day 46 and declined
rapidly to 850 pg/ml at Day 55 before gradually rising to a second high level. The concentration in
amniotic fluid followed that in allantoic fluid, but no second peak was evident. The pattern for the
concentration of unconjugated estrone was similar to that of the sulfoconjugate, but at a very
much lower level. The change in the concentration of the estradiol sulfates was similar to that for
estrone sulfate. An estimate was obtained for the radio of the amounts of estradiol-17 The possible roles of estrogen during early pregnancy are discussed.
to estradiol-17
which were present. In the maternal fluids, estrone sulfate was again the major estrogen
present, but it was not readily detectable in the jugular venous plasma until approximately Day 50.
Note:
ACKNOWLEDGMENTS
We wish to acknowledge the technical advice
freely given by R. Durnford. These assays were made
possible by a gift of antisera to estrogens by Dr. B. V.
Caldwell and [3H]estradiol-17 by Dr. D. S. Layne.
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