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Biology of Reproduction, Vol 19, 597-605, Copyright © 1978 by Society for the Study of Reproduction
1 Reproductive Endocrinology Program,
Division of Biological Science,
and
Department of Pathology,
The University of Michigan,
Ann Arbor, Michigan 48109 Ovarian follicular development was examined in the cycling rat using histological techniques. The number and size distribution of
follicles was determined for each day of the estrous cycle. While the number of follicles in the early stages of growth did not appear to
vary dramatically throughout the estrous cycle, the final stages of growth and differentiation showed great variation throughout the
cycle. No follicles of 390-500 µm were seen on proestrus, bus many appeared the next day suggesting that there was a discontinuous
movement of follicles into the largest size range. Follicular atresia was most marked in follicles 200-400 µm in diameter suggesting that
there may be a critical stage during follicular development when, unless rescued, most follicles become atretic.
Note:
ACKNOWLEDGMENTS
This research was supported in part by a
Program Project in Reproductive Endocrinology
(HD-08333) and a grant from the Ford
Foundation. We thank Dr. JoAnne S. Richards
for her valuable suggestions and critical review of
the manuscript.
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