Biol Reprod 2009 SSR Annual Meeting Abstracts
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Biology of Reproduction, Vol 19, 612-619, Copyright © 1978 by Society for the Study of Reproduction

Ovarian-Dependent Development of a Stimulatory Effect of 5agr-Dihydrotestosterone on Serum Follicle Stimulating Hormone in the Ovariectomized Rat

G. T. CAMPBELL 1, and J. A. RAMALEY 1

1 Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, Nebraska 68105


The data presented here indicate that s.c. implants of 5agr-dihydrotestosterone (DHT) produce a biphasic effect on serum FSH, an initial elevation through about 48 h followed by a decline, in rats ovariectomized as adults. Only the suppressive effects of DHT were observed in orchidectomized rats and the stimulatory effect of DHT in ovariectomized rats was not shared by testosterone. In another study, in which rats were gonadectomized at various ages, several days of DHT treatment suppressed serum FSH levels if ovariectomies were performed on or before Day 8 of postnatal life, whereas serum FSH was suppressed in orchidectomized rats by DHT regardless of the age at which orchidectomies were performed. Other results showed that the initial stimulatory effect of DHT on serum FSH in ovariectomized rats was observed if the rats were ovariectomized on Day 9 or later. These data suggest that the development of mechanisms responsible for a DHT-induced elevation of serum FSH in ovariectomized rats is dependent upon differentiation of the ovarian-brain-pituitary system and occurs during the second postnatal week.

Note:
ACKNOWLEDGMENTS We wish to express our sincere thanks to Jack Wagoner, Sharon Clawson, Mary Alyce Vornholt, Tim Grinbergs and Charles Berdanier for their excellent technical assistance and to the secretarial assistants of the department for lending us their clerical skills. Our gratitude is also extended to Dr. A. S. Bhatnagar, Department of Obstetrics and Gynecology, Medical College of Virginia, Richmond, Virginia, for computerizing the data for us. We wish to thank Dr. G. D. Niswender for the LH antiserum (GN-15) and Dr. A. F. Parlow and The Hormone Distribution Officer, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, 26014, for other reagents used in radioimmunoassays.

Submitted on October 18, 1977
Accepted on April 7, 1978






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Copyright © 1978 by the Society for the Study of Reproduction.